Project Description

Fisetin (CAS 528-48-3)

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Basic information

  • Product Name: Fisetin
  • Alternative Names: 3,3′,4′,7-Tetrahydroxyflavone
  • Description: A potent natural flavonoid with excellent antioxidant, anti-inflammatory, anti-aging and neuroprotective activities, widely studied for cellular senescence clearance and metabolic regulation effects.
  • Purity: ≥98% (HPLC)
  • Type of Compound: Flavonoids (Flavonol subclass)
  • Physical Description: Yellow Fine Powder
  • Herb Source: Natural plant extracts from Rhus succedanea, Acacia confusa, and multiple fruits and vegetables
  • Part Used: Plant bark, fruit and leaf extracts

Specifications

M. Wt 286.24
Formula C15H10O6
Storage
Store at +4°C, sealed and protected from light and moisture
Purity ≥98% (HPLC)
CAS Number
528-48-3
PubChem ID
5281614
InChI Key
XLYOFNOQVPJJNP-UHFFFAOYSA-N
Smiles
C1=CC(=C(C=C1O)O)C2=C(O)C(=O)C3=C(C=C(C=C3O2)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

What is Fisetin

Fisetin is a naturally occurring bioactive flavonol belonging to the flavonoid family, renowned for its superior biological activity and high bioavailability compared with other flavonoids. It is abundantly present in a variety of daily fruits and vegetables, including strawberries, apples, persimmons, grapes, onions, and cucumbers. As a natural senolytic compound, Fisetin is widely researched in anti-aging, cellular health maintenance, and chronic disease intervention. It effectively scavenges excess free radicals in the human body, regulates inflammatory responses, and supports overall bodily metabolism, making it a core raw material for functional health products, pharmaceutical research and cosmetic development.

Biological Activity

Fisetin exhibits powerful antioxidant, anti-inflammatory, senolytic and anti-proliferative biological activities. It effectively inhibits LPS-induced inflammatory mediators including TNF-α, IL-1β, and IL-6, and suppresses the activation of NF-κB inflammatory signaling pathway. Additionally, it downregulates the expression of inducible nitric oxide synthase (iNOS) and COX-2 to alleviate chronic inflammation. Fisetin selectively eliminates senescent cells, inhibits the proliferation of various cancer cells, induces tumor cell apoptosis, and exerts significant neuroprotective and anti-oxidative stress effects. It also regulates lipid metabolism and improves cellular energy metabolism.

What are the benefits of Fisetin

  • Powerful Antioxidant Effect: Fisetin possesses strong free radical scavenging capacity, effectively neutralizing reactive oxygen species (ROS), reducing oxidative damage to cells and delaying skin and body aging.
  • Anti-Inflammatory & Immunomodulatory: It relieves acute and chronic inflammatory reactions, regulates immune cell activity, and reduces inflammatory damage to tissues and organs.
  • Anti-Tumor & Chemopreventive Effect: Inhibits the proliferation, migration and invasion of multiple tumor cells, including lung cancer, liver cancer, breast cancer and colon cancer, and assists in tumor prevention and adjuvant treatment.
  • Anti-Aging & Senolytic Activity: As a classic natural senolytic agent, it clears accumulated senescent cells in the body, improves tissue vitality, and delays age-related functional decline.
  • Neuroprotective Function: Protects nerve cells from oxidative damage and inflammatory injury, improves cognitive function, and helps prevent neurodegenerative diseases.
  • Hepatic & Metabolic Protection: Reduces liver oxidative stress and fatty liver damage, regulates blood sugar and lipid metabolism, and protects cardiovascular health.
  • Anti-Allergic & Anti-Microbial: Inhibits allergic reactions and has certain inhibitory effects on harmful bacteria and viruses, improving body resistance.

Applications of Fisetin

  • Health Product Field: As a high-purity functional raw material, Fisetin powder is widely used in anti-aging supplements, cellular health capsules, antioxidant tablets and immune regulation products, supporting body anti-oxidation and anti-aging maintenance.
  • Pharmaceutical Research Field: Applied in the research and development of anti-inflammatory, anti-tumor, neuroprotective and metabolic regulation drugs, serving as an important active intermediate for new drug development.
  • Cosmetic Field: Utilized as a natural anti-aging and antioxidant raw material in skin care products, it improves skin oxidative aging, fades free radical damage, and enhances skin elasticity and vitality.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 1.43 5
DMSO 14.31 50
Ethanol 7.16 25

Product Datasheets

Certificate of Analysis Safety Datasheet
Safety Datasheet

Safety Datasheet

Packing&Storage

  1. 1-5kg with double plastic container inside/aluminum foil bag outside. 10kg with double plastic container inside/carton outside. 25kg with double plastic container inside/fiber drum outside or it is at your option.
  2. Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.
  3. Shelf Life: Two years under well storage situation.

plant extract package

Transport&Payment

  • Small package sent by EMS, UPS, FedEx, DHL, etc.
  • Payment available for Western Union, T/T, Paypal, etc.
  • Cargo sent by Air or By Sea is all available.
    By Express By Air By Sea
    Suitable for under 50kg Suitable for more than 50kg Suitable for more than 500kg
    Delivery time: 4-5days Delivery time: 5-7days Delivery time: 15-30days
    Door to door service Airport to Airport Port to Port
    Easy to pick up the goods Professional broker needed Professional broker needed

     

Certifications